459193-26-1
Chemical Structure
c-Met/STAT3-IN-2
- CAS No.: 459193-26-1
- Formula:C23H21FN4S
- Molecular Weight:404.50
InChIKey: PJYYKAKEODCFAG-UHFFFAOYSA-N
SMILES: FC1=CC=C(C2=CSC3=NC=NC(N4CCN(CC5=CC=CC=C5)CC4)=C32)C=C1
Biological Activity: c-Met/STAT3-IN-2 is a c-Met and STAT3 inhibitor with IC50 values of 0.20 μM and 0.74 μM, respectively. c-Met/STAT3-IN-2 inhibits c-Met and STAT3 phosphorylation, binds to the STAT3 SH2 domain, and blocks pTyr705 recognition. c-Met/STAT3-IN-2 induces cancer cell apoptosis (apoptosis) and G2/M phase arrest, upregulates P53, Bax, PUMA, caspases-3, -8, and -9, and downregulates Bcl-2. c-Met/STAT3-IN-2 has broad-spectrum anticancer activity, inhibits cancer cell proliferation, and exhibits lethal activity against various cancer cell lines. c-Met/STAT3-IN-2 shows minimal off-target inhibition of STK3, STK4, PI3Kdelta, and VEGFR3. c-Met/STAT3-IN-2 can be used for research related to colorectal cancer, leukemia, non-small cell lung cancer, and breast cancer cells[1].
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c-Met/STAT3-IN-2 | c-Met/STAT3-IN-2 is a c-Met and STAT3 inhibitor with IC50 values of 0.20 μM and 0.74 μM, respectively. c-Met/STAT3-IN-2 inhibits c-Met and STAT3 phosphorylation, binds to the STAT3 SH2 domain, and blocks pTyr705 recognition. c-Met/STAT3-IN-2 induces cancer cell apoptosis (apoptosis) and G2/M phase arrest, upregulates P53, Bax, PUMA, caspases-3, -8, and -9, and downregulates Bcl-2. c-Met/STAT3-IN-2 has broad-spectrum anticancer activity, inhibits cancer cell proliferation, and exhibits lethal activity against various cancer cell lines. c-Met/STAT3-IN-2 shows minimal off-target inhibition of STK3, STK4, PI3Kdelta, and VEGFR3. c-Met/STAT3-IN-2 can be used for research related to colorectal cancer, leukemia, non-small cell lung cancer, and breast cancer cells. | |||||||||||||||||||||
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