4638-48-6
Chemical Structure
5-Chlorosalicylanilide
- CAS No.: 4638-48-6
- Formula:C13H10ClNO2
- Molecular Weight:247.68
IUPAC Name: 5-chloro-2-hydroxy-N-phenylbenzamide
InChIKey: KGYNGVVNFRUOOZ-UHFFFAOYSA-N
SMILES: O=C(NC=1C=CC=CC1)C2=CC(Cl)=CC=C2O
Biological Activity: 5-Chlorosalicylanilide is a bactericidal and antifungal compound. 5-Chlorosalicylanilide exhibits antibacterial activity against bacteria and fungistatic activity against dermatophytes. 5-Chlorosalicylanilide inhibits the photosynthetic electron flow required for nitrite reduction while stimulating nitrate reduction, leading to nitrite accumulation and NOx release in soybean leaves. 5-Chlorosalicylanilide is used in the research of tinea capitis and dermatophytosis[1][2][3][4][5].
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5-Chlorosalicylanilide | 5-Chlorosalicylanilide is a bactericidal and antifungal compound. 5-Chlorosalicylanilide exhibits antibacterial activity against bacteria and fungistatic activity against dermatophytes. 5-Chlorosalicylanilide inhibits the photosynthetic electron flow required for nitrite reduction while stimulating nitrate reduction, leading to nitrite accumulation and NOx release in soybean leaves. 5-Chlorosalicylanilide is used in the research of tinea capitis and dermatophytosis. | |||||||||||||||||||||
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References
- [1]. The Procter & Gamble Company. WO 02/05643 A2. International application published under the Patent Cooperation Treaty; 2002 Jan 24.
- [2]. Klepper L. NOₓ evolution by soybean leaves treated with salicylic acid and selected derivatives. Pestic Biochem Physiol. 1991;39(1):43‑48.
- [3]. THORNE NA, et al. A survey of tinea capitis five years after treatment by x-ray epilation. Postgrad Med J. 1954 Aug;30(346):423-4.
- [4]. Lin S, et al. Solid‑phase extraction coupled with ultra performance liquid chromatography tandem mass spectrometry to determine seven halogenated salicylanilides in cosmetics. RSC Adv. 2016;6(54):49011‑49018.
- [5]. BAICHWAL RS, et al. The lack of a reversing effect of certain metallic ions on the inhibitory action of salicylanilide. Can J Microbiol. 1960 Oct;6:595-7.
