468-61-1
468-61-1
Chemical Structure
Oxeladin
- CAS No.: 468-61-1
- Formula:C20H33NO3
- Molecular Weight:335.48
IUPAC Name: 2-(2-(diethylamino)ethoxy)ethyl 2-ethyl-2-phenylbutanoate
InChIKey: IQADUMSPOQKAAO-UHFFFAOYSA-N
SMILES: O=C(OCCOCCN(CC)CC)C(CC)(CC)C1=CC=CC=C1
Biological Activity: Oxeladin is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM). Oxeladin can be used for pulmonary diseases and stroke research[1][2].
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Oxeladin | Oxeladin is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM). Oxeladin can be used for pulmonary diseases and stroke research. | |||||||||||||||||||||
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References
- [1]. Schreihofer DA, et al. Treatment of Stroke at a Delayed Timepoint with a Repurposed Drug Targeting Sigma 1 Receptors. Transl Stroke Res. 2023. Epub ahead of print. [Content Brief]
- [2]. Dalwadi DA, et al. Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands. J Pharmacol Toxicol Methods. 2022;113:107129. [Content Brief]
