469-32-9
469-32-9
Chemical Structure
Hamamelitannin
- CAS No.: 469-32-9
- Formula:C20H20O14
- Molecular Weight:484.36
IUPAC Name: (2R,3R,4R)-2-formyl-2,3,4-trihydroxypentane-1,5-diyl bis(3,4,5-trihydroxybenzoate)
InChIKey: STINYPFJROKCKD-WIBUTAKZSA-N
SMILES: O=C[C@]([C@@H]([C@@H](COC(C1=CC(O)=C(O)C(O)=C1)=O)O)O)(COC(C2=CC(O)=C(O)C(O)=C2)=O)O
Biological Activity: Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hamamelitannin | 99.38% | Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release. | ||||||||||||||||||||
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References
- [1]. Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73(5):1578-86. [Content Brief]
- [2]. Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68(1):126-30. [Content Brief]
