470-94-0
Chemical Structure
N-Demethyl amiton oxalic
- CAS No.: 470-94-0
- Formula:C10H22NO7PS
- Molecular Weight:331.32
IUPAC Name: S-(2-(dimethylamino)ethyl) O,O-diethyl phosphorothioate oxalate
InChIKey: PXPPTYPWWLDKPW-UHFFFAOYSA-N
SMILES: O=C(C(O)=O)O.O=P(OCC)(SCCN(C)C)OCC
Biological Activity: N-Demethyl amiton oxalic is an irreversible cholinesterase (ChE) inhibitor. N-Demethyl amiton oxalic elicits low-level postganglionic neuronal firing in cat vesical parasympathetic ganglia by preventing the breakdown of endogenously released ChE. N-Demethyl amiton oxalic inhibits ChE activity in squid optic ganglia and induces hyperactivity, ink ejection, pigment changes, and death, with a rate of enzymatic detoxification much lower than that of DFP. N-Demethyl amiton oxalic can be used in studies related to the mechanisms of cholinergic transmission in parasympathetic ganglia and neurotoxicology[1][2].
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N-Demethyl amiton oxalic | N-Demethyl amiton oxalic is an irreversible cholinesterase (ChE) inhibitor. N-Demethyl amiton oxalic elicits low-level postganglionic neuronal firing in cat vesical parasympathetic ganglia by preventing the breakdown of endogenously released ChE. N-Demethyl amiton oxalic inhibits ChE activity in squid optic ganglia and induces hyperactivity, ink ejection, pigment changes, and death, with a rate of enzymatic detoxification much lower than that of DFP. N-Demethyl amiton oxalic can be used in studies related to the mechanisms of cholinergic transmission in parasympathetic ganglia and neurotoxicology. | |||||||||||||||||||||
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References
- [1]. Dettbarn WD, et al. Toxicity of DFP and related compounds to squids in relation to cholinesterase inhibition and detoxifying enzyme levels. Bull Environ Contam Toxicol. 1975 Feb;13(2):133-40.
- [2]. Kawatani M, et al. Selective facilitatory effect of vasoactive intestinal polypeptide (VIP) on muscarinic firing in vesical ganglia of the cat. Brain research. 1985 Jun 17;336(2):223-34.
