47132-16-1
Chemical Structure
(E)-10-Hydroxynortriptyline
Synonym(s): E-10-OH-NT
- CAS No.: 47132-16-1
- Formula:C19H21NO
- Molecular Weight:279.38
IUPAC Name: (E)-5-(3-(methylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol
InChIKey: VAGXZGJKNUNLHK-LFIBNONCSA-N
SMILES: OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC
Biological Activity: (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression[1][2].
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(E)-10-Hydroxynortriptyline | 99.36% | (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression. | ||||||||||||||||||||
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(E)-10-Hydroxynortriptyline-d3 | 99.65% | (E)-10-Hydroxynortriptyline-d3 (E-10-OH-NT-d3) is the deuterated-labeled (E)-10-Hydroxynortriptyline (HY-U00050). (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression. | ||||||||||||||||||||
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References
- [1]. Nordin C, et al. Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects. Clin Pharmacol Ther. 1987;41(1):97-102. [Content Brief]
- [2]. Bertilsson L, et al. E-10-hydroxynortriptyline: effects and disposition of a potential novel antidepressant[J]. Clinical Pharmacology in Psychiatry: From Molecular Studies to Clinical Reality, 1989: 52-59.
