473-41-6
473-41-6
Chemical Structure
Tolbutamide sodium
- CAS No.: 473-41-6
- Formula:C12H18N2NaO3S
- Molecular Weight:293.34
IUPAC Name: N-(butylcarbamoyl)-4-methylbenzenesulfonamide, sodium salt
InChIKey: PJBDAJOVTMHXOQ-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C)C=C1)(NC(NCCCC)=O)=O.[Na]
Biological Activity: Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus[1][2].
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Tolbutamide sodium | Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. Trube G, et al. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986 Nov;407(5):493-9. [Content Brief]
- [2]. Efanova IB, et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem. 1998 Dec 11;273(50):33501-7. [Content Brief]
