473-42-7
Chemical Structure
Nitrosulfathiazole
Synonym(s): Nisulfazole; p-Nitrosulfathiazole
- CAS No.: 473-42-7
- Formula:C9H7N3O4S2
- Molecular Weight:285.30
IUPAC Name: 4-nitro-N-(thiazol-2-yl)benzenesulfonamide
InChIKey: CIASIHHEOGXVOM-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C([N+]([O-])=O)C=C1)(NC2=NC=CS2)=O
Biological Activity: Nitrosulfathiazole (Nisulfazole; p-Nitrosulfathiazole) is a sulfonamide antibacterial agent and also a key chemical intermediate for the hematotoxicity of Chloramphenicol (HY-B0239). Nitrosulfathiazole induces DNA helix instability, strand breakage and aplastic anemia. Nitrosulfathiazole can be used in research related to bacterial infections and aplastic anemia[1][2].
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Nitrosulfathiazole | Nitrosulfathiazole (Nisulfazole; p-Nitrosulfathiazole) is a sulfonamide antibacterial agent and also a key chemical intermediate for the hematotoxicity of Chloramphenicol (HY-B0239). Nitrosulfathiazole induces DNA helix instability, strand breakage and aplastic anemia. Nitrosulfathiazole can be used in research related to bacterial infections and aplastic anemia. | |||||||||||||||||||||
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References
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[1]. Shukla, P., & Singh, R. K. (2013). Effect of oral administration of chloramphenicol on hematological profile of male charles foster rats. Global journal of medical research pharma, drug discovery, toxicology and medicine, 13.
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[2]. Holt D, et al. Chloramphenicol toxicity. Adverse Drug React Toxicol Rev. 1993 Summer;12(2):83-95. PMID: 8357947.
[Content Brief]
