473289-62-2
Chemical Structure
Ilepatril
Synonym(s): AVE 7688
- CAS No.: 473289-62-2
- Formula:C22H28N2O5S
- Molecular Weight:432.53
IUPAC Name: (4S,7S,12bR)-7-((S)-2-(acetylthio)-3-methylbutanamido)-6-oxo-1,2,3,4,6,7,8,12b-octahydrobenzo[c]pyrido[1,2-a]azepine-4-carboxylic acid
InChIKey: FXKFFTMLFPWYFH-RDGPPVDQSA-N
SMILES: O=C([C@@H]1CCC[C@]2([H])C3=CC=CC=C3C[C@H](NC([C@@H](SC(C)=O)C(C)C)=O)C(N21)=O)O
Biological Activity: Ilepatril, a dual inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase, has inhibitory effects in the type 2 diabetic nephropathy model in obese Zucker diabetic fatty (ZDF) rats. Ilepatril significantly reduced albuminuria in a dose-dependent manner and may be a strategy distinct from metabolic control to inhibit type 2 diabetic nephropathy[1].
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Ilepatril | Ilepatril, a dual inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase, has inhibitory effects in the type 2 diabetic nephropathy model in obese Zucker diabetic fatty (ZDF) rats. Ilepatril significantly reduced albuminuria in a dose-dependent manner and may be a strategy distinct from metabolic control to inhibit type 2 diabetic nephropathy. | |||||||||||||||||||||
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