475115-35-6
475115-35-6
Chemical Structure
Galnon
- CAS No.: 475115-35-6
- Formula:C40H46N4O6
- Molecular Weight:678.82
IUPAC Name: (9H-fluoren-9-yl)methyl ((S)-1-(((S)-6-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)carbamate
InChIKey: IKNOZZKXIDSTRN-PXLJZGITSA-N
SMILES: O=C(N[C@H](C(N[C@@H](CCCCN)C(NC1=CC=C(C(C)=C2)C(OC2=O)=C1)=O)=O)CC3CCCCC3)OCC4C5=CC=CC=C5C6=CC=CC=C46
Biological Activity: Galnon is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon exhibits anticonvulsant and anxiolytic effects[1][2].
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Galnon | Galnon is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon exhibits anticonvulsant and anxiolytic effects. | |||||||||||||||||||||
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References
- [1]. Bartfai T, et, al. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5. [Content Brief]
- [2]. Rajarao SJR, et, al. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides. 2007 Oct;41(5):307-20. [Content Brief]
