475673-78-0
Chemical Structure
Sterekunthal B
- CAS No.: 475673-78-0
- Formula:C20H18O4
- Molecular Weight:322.35
InChIKey: NSNGIRMJTMEZBF-YJKZWKBDSA-N
SMILES: O=C[C@@]1([C@@]23C(C(C4=CC=CC=C4C3=O)=O)=C[C@@]5([H])[C@]1([H])CC[C@]5(O2)C)C
Biological Activity: Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research[1][2][3].
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Sterekunthal B | Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research. | |||||||||||||||||||||
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References
- [1]. Malerich JP, et al. Biomimetic synthesis of antimalarial naphthoquinones. J Am Chem Soc. 2005 May 4;127(17):6276-83. [Content Brief]
- [2]. Onegi B, et al. Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum. Phytochemistry. 2002;60(1):39-44. [Content Brief]
- [3]. Oloche J J, et al. Review of phytochemical, pharmacological and toxicological profile of Stereospermum kunthianum[J]. J Adv Med Pharm Sci, 2016, 5(1): 1-10.
