4758-99-0
4758-99-0
Chemical Structure
Guanfu base H
Synonym(s): Atisinium chloride
- CAS No.: 4758-99-0
- Formula:C22H34ClNO2
- Molecular Weight:379.96
InChIKey: CTQGDDPQMCXQJW-NWDYWHSLSA-M
SMILES: O[C@H]1[C@]23[C@](C[C@@](CC3)([H])C1=C)([H])[C@]45[C@]([C@](C[N+](CCO)=C4)(CCC5)C)([H])CC2.[Cl-]
Biological Activity: Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Guanfu base H | 99.18% | Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively. | ||||||||||||||||||||
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3-Deoxyaphidicolin | 3-Deoxyaphidicolin exhibits phytotoxic efficacy, that inhibits root growth of lettuce seedlings. 3-Deoxyaphidicolin also exhibits leishmanicidal activity against Leishmania major and Leishmania braziliensis. | |||||||||||||||||||||
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2β,15α-Dihydroxy-ent-kaur-16-ene | 2β,15α-Dihydroxy-ent-kaur-16-ene is a natural diterpene. | |||||||||||||||||||||
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Ent-11α,12α,15α-trihydroxykaur-16-en-19-oic Acid | Ent-11α,12α,15α-trihydroxykaur-16-en-19-oic Acid is a natural diterpene. | |||||||||||||||||||||
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Denudatine | Denudatine, is primarily isolated from plants of the genera Aconitum and Delphinium. Denudatine has effects on action potential of ventricular fibers and inhibits arrhythmogenic action of aconitine. | |||||||||||||||||||||
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Deacetylxylopic acid | Deacetylxylopic acid (ent-15α-Hydroxykaurenoic acid) is a Diterpene product that can be isolated from Blumea eriantha. | |||||||||||||||||||||
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(4α,11β,15β)-11,15-Dihydroxykaur-16-en-19-oic acid | (4α,11β,15β)-11,15-Dihydroxykaur-16-en-19-oic acid is a compound isolated from the Tunisian Pulicaria laciniata (Coss.et Kral.) Thell. flowers. | |||||||||||||||||||||
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ent-16-Kaurene-3b,15b,18-triol | ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen. | |||||||||||||||||||||
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Grandifloric acid | Grandifloric acid is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis L.. | |||||||||||||||||||||
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Bullatine A | 98.0% | Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression. | ||||||||||||||||||||
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Dictysine | Dictysine is a natural product. | |||||||||||||||||||||
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References
- [1]. WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-233.
- [2]. Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130(3):559-62. [Content Brief]
