478926-45-3
Chemical Structure
E-3030 free acid
- CAS No.: 478926-45-3
- Formula:C22H23ClFNO5
- Molecular Weight:435.87
IUPAC Name: (S)-3-(3-((S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy)phenyl)-2-isopropoxypropanoic acid
InChIKey: QICKBMIIFBKLBR-RXVVDRJESA-N
SMILES: O=C(O)[C@@H](OC(C)C)CC1=CC=CC(OC[C@H](F)COC2=CC=C(Cl)C=C2C#N)=C1
Biological Activity: E-3030 free acid is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, exhibiting significant antidiabetic and lipid-modulating effects. E-3030 decreases blood glucose, triglyceride, non-esterified fatty acids, and insulin levels, while increasing blood adiponectin levels. E-3030 improves glucose tolerance and shows remarkable triglyceride- and non-high-density lipoprotein cholesterol-lowering effects in animal models.
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E-3030 free acid | E-3030 free acid is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, exhibiting significant antidiabetic and lipid-modulating effects. E-3030 decreases blood glucose, triglyceride, non-esterified fatty acids, and insulin levels, while increasing blood adiponectin levels. E-3030 improves glucose tolerance and shows remarkable triglyceride- and non-high-density lipoprotein cholesterol-lowering effects in animal models. | |||||||||||||||||||||
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