480452-24-2
Chemical Structure
Antibiofilm agent-12
- CAS No.: 480452-24-2
- Formula:C13H11ClN2O2
- Molecular Weight:262.69
InChIKey: KKENYRKTZAIZKB-UHFFFAOYSA-N
SMILES: O=C(NNC1=CC=C(Cl)C=C1)OC2=CC=CC=C2
Biological Activity: Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model[1].
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Antibiofilm agent-12 | Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model. | |||||||||||||||||||||
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