48144-44-1
Chemical Structure
m-Chlorophenylbiguanide
Synonym(s): mCPBG
- CAS No.: 48144-44-1
- Formula:C8H10ClN5
- Molecular Weight:211.65
InChIKey: DIHXJZHAIHGSAW-UHFFFAOYSA-N
SMILES: N=C(NC1=CC=CC(Cl)=C1)NC(N)=N
Biological Activity: m-Chlorophenylbiguanide (mCPBG) is a potent high-affinity agonist of the 5-HT3 receptor, exhibiting an inhibitory effect on long-term potentiation (LTP) in the mossy fiber-CA3 system. mCPBG attenuates the magnitude of LTP at concentrations of 0.3-1 microM, demonstrating its role in modulating synaptic plasticity. Additionally, the impact of mCPBG on LTP is reversible by the GABAA receptor antagonist bicuculline, indicating a connection between its action and GABAergic neurotransmission.
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m-Chlorophenylbiguanide | m-Chlorophenylbiguanide (mCPBG) is a potent high-affinity agonist of the 5-HT3 receptor, exhibiting an inhibitory effect on long-term potentiation (LTP) in the mossy fiber-CA3 system. mCPBG attenuates the magnitude of LTP at concentrations of 0.3-1 microM, demonstrating its role in modulating synaptic plasticity. Additionally, the impact of mCPBG on LTP is reversible by the GABAA receptor antagonist bicuculline, indicating a connection between its action and GABAergic neurotransmission. | |||||||||||||||||||||
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