481724-82-7
481724-82-7
Chemical Structure
CGP-74514 hydrochloride
Synonym(s): CGP-74514A
- CAS No.: 481724-82-7
- Formula:C19H25Cl2N7
- Molecular Weight:422.35
IUPAC Name: N2-((1S,2R)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine hydrochloride
InChIKey: GDCXPZPXAWTYJM-LIOBNPLQSA-N
SMILES: CCN1C2=NC(N[C@@H]3[C@@H](CCCC3)N)=NC(NC4=CC(Cl)=CC=C4)=C2N=C1.Cl
Biological Activity: CGP-74514 hydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50: 25 nM). CGP-74514 hydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 hydrochloride is promising for research of bladder cancer[1][2].
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CGP-74514 hydrochloride | CGP-74514 hydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50: 25 nM). CGP-74514 hydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 hydrochloride is promising for research of bladder cancer. | |||||||||||||||||||||
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References
- [1]. Furet P, et al. Structure-based design of potent CDK1 inhibitors derived from olomoucine. J Comput Aided Mol Des. 2000 Jul;14(5):403-9. [Content Brief]
- [2]. Imbach P, et al. 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. [Content Brief]
