484-08-2
484-08-2
Chemical Structure
Kokusaginine
- CAS No.: 484-08-2
- Formula:C14H13NO4
- Molecular Weight:259.26
IUPAC Name: 4,6,7-trimethoxyfuro[2,3-b]quinoline
InChIKey: JBRXRVFXQIKPEA-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(OC)=C3C(OC=C3)=NC2=C1)OC
Biological Activity: Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2].
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Kokusaginine | 98% | Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells. | ||||||||||||||||||||
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References
- [1]. Sichaem J, et al., Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015 Aug;10(8):1359-62. [Content Brief]
- [2]. Chen H, et al., The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2490-2492. [Content Brief]
