484-43-5
Chemical Structure
5-Valine-angiotensin I
- CAS No.: 484-43-5
- Formula:C61H87N17O14
- Molecular Weight:1282.45
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC4=CN=CN4)=O)CC5=CC=CC=C5)=O)=O)=O)=O
Biological Activity: 5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone[1][2].
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5-Valine-angiotensin I | 5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone. | |||||||||||||||||||||
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References
- [1]. Hayashi Y, et al. Synthesis and specific pressor activity of [1-aspartic acid,5-valine,9-serine]angiotensin I ("fowl angiotensin I"). J Med Chem. 1977 Feb;20(2):315-6. [Content Brief]
- [2]. Myshlyakova, et al. Pharmacological characteristics of "active sites" of the angiotensin. Khimiko-Farmatsevticheskii Zhurnal, 1977, 11(7):6-11. [Russian]
