488815-65-2
Chemical Structure
10-Butyl Ether Minocycline
Synonym(s): BEM
- CAS No.: 488815-65-2
- Formula:C27H35N3O7
- Molecular Weight:513.58
IUPAC Name: (4S,4aS,5aR,12aS)-10-butoxy-4,7-bis(dimethylamino)-3,12,12a-trihydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
InChIKey: BULDRVDTZGMCPY-NXBJZFPUSA-N
SMILES: [H][C@@]12C[C@@]3(CC4=C(C=CC(OCCCC)=C4C(C3=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)=O)N(C)C)[H]
Biological Activity: 10-Butyl Ether Minocycline (BEM), a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056)-induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390)-induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD)[1].
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10-Butyl Ether Minocycline | 10-Butyl Ether Minocycline (BEM), a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056)-induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390)-induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD). | |||||||||||||||||||||
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