4904-00-1
Chemical Structure
Cyprolidol
- CAS No.: 4904-00-1
- Formula:C21H19NO
- Molecular Weight:301.38
InChIKey: KPUSUIKQQCFQCX-VQTJNVASSA-N
SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3[C@H](C4=CC=NC=C4)C3
Biological Activity: Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression[1].
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Cyprolidol | Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression. | |||||||||||||||||||||
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