491845-95-5
Chemical Structure
RY764
- CAS No.: 491845-95-5
- Formula:C34H51FN4O3
- Molecular Weight:582.79
IUPAC Name: (1R,4S,6R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl)-3-(4-fluorophenyl)-1-oxopropan-2-yl)-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide
InChIKey: ARFBDECCXOFCBN-HOLBEBDISA-N
SMILES: CC(C)(C)NC(C1(C2CCCCC2)CCN(CC1)C([C@H](NC([C@H]3[C@]4([H])N(C[C@](CC4)([H])C3)C)=O)CC5=CC=C(C=C5)F)=O)=O
Biological Activity: RY764 is an orally active and selective MC4R agonist. RY764 binds human MC4R with IC50 = 8 nM; it stimulates cAMP accumulation with EC50 = 11 nM. RY764 produces mechanism-dependent feeding inhibition and pro-erectile activity in rodent models. RY764 is used in research on obesity and sexual function[1].
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RY764 | RY764 is an orally active and selective MC4R agonist. RY764 binds human MC4R with IC50 = 8 nM; it stimulates cAMP accumulation with EC50 = 11 nM. RY764 produces mechanism-dependent feeding inhibition and pro-erectile activity in rodent models. RY764 is used in research on obesity and sexual function. | |||||||||||||||||||||
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References
- [1]. Ye Z, et al. Discovery and activity of (1R, 4S, 6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1, 1-dimethylethyl) amino] carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl) methyl]-2-oxoethyl]-2-methyl-2-azabicyclo [2.2. 2] octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist. Bioorganic & medicinal chemistry letters. 2005 Aug 1;15(15):3501-5. [Content Brief]
