497258-53-4
Chemical Structure
5-Taurinomethyluridine
- CAS No.: 497258-53-4
- Formula:C12H19N3O9S
- Molecular Weight:381.36
IUPAC Name: 2-(((1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)amino)ethane-1-sulfonic acid
InChIKey: VJKJOPUEUOTEBX-TURQNECASA-N
SMILES: O=S(CCNCC(C(N1)=O)=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1=O)(O)=O
Biological Activity: 5-Taurinomethyluridine is a taurine-containing modified uridine and translation regulator that exists in Trp and Leu (UUR) tRNAs of mammalian mitochondria. 5-Taurinomethyluridine is located at the first position of the anticodon of these mitochondrial tRNAs. 5-Taurinomethyluridine is synthesized from taurine and one-carbon metabolites by GTPBP3/MTO1, and its deficiency directly causes abnormal mitochondrial translation and various human mitochondrial diseases[1][2].
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5-Taurinomethyluridine | 5-Taurinomethyluridine is a taurine-containing modified uridine and translation regulator that exists in Trp and Leu (UUR) tRNAs of mammalian mitochondria. 5-Taurinomethyluridine is located at the first position of the anticodon of these mitochondrial tRNAs. 5-Taurinomethyluridine is synthesized from taurine and one-carbon metabolites by GTPBP3/MTO1, and its deficiency directly causes abnormal mitochondrial translation and various human mitochondrial diseases. | |||||||||||||||||||||
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References
- [1]. Suzuki T, et al. Novel taurine-containing uridine derivatives and mitochondrial human diseases. Nucleic Acids Res Suppl. 2001;(1):257-258. [Content Brief]
- [2]. Asano K, et al. Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. Nucleic Acids Res. 2018;46(4):1565-1583. [Content Brief]
