49752-90-1
Chemical Structure
(Rac)-Mefloquine
Synonym(s): (Rac)-Mefloquin
- CAS No.: 49752-90-1
- Formula:C17H16F6N2O
- Molecular Weight:378.32
IUPAC Name: (2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol
InChIKey: XEEQGYMUWCZPDN-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=NC2=C(C=CC=C2C(F)(F)F)C(=C1)C(O)C3NCCCC3
Biological Activity: (Rac)-Mefloquine ((Rac)-Mefloquin) is an orally active NF-κB inhibitor. (Rac)-Mefloquine inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB-Luc luciferase activity, blocks the activation of p65 and IκBα, and reduces the expression of downstream target genes of NF-κB. (Rac)-Mefloquine activates apoptosis-related factors and induces apoptosis in tumor cells. (Rac)-Mefloquine functions as a tumor cell inhibitor. (Rac)-Mefloquine can be used for the research of colorectal cancer[1].
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(Rac)-Mefloquine | (Rac)-Mefloquine ((Rac)-Mefloquin) is an orally active NF-κB inhibitor. (Rac)-Mefloquine inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB-Luc luciferase activity, blocks the activation of p65 and IκBα, and reduces the expression of downstream target genes of NF-κB. (Rac)-Mefloquine activates apoptosis-related factors and induces apoptosis in tumor cells. (Rac)-Mefloquine functions as a tumor cell inhibitor. (Rac)-Mefloquine can be used for the research of colorectal cancer. | |||||||||||||||||||||
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