497871-47-3
497871-47-3
Chemical Structure
Lurbinectedin
Synonym(s): PM01183; LY-01017
- CAS No.: 497871-47-3
- Formula:C41H44N4O10S
- Molecular Weight:784.87
InChIKey: YDDMIZRDDREKEP-HWTBNCOESA-N
SMILES: O[C@@H]([C@@](CC1=CC(C)=C2OC)([H])N(C)[C@]3([H])C1=C2O)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]3([H])[C@@](SC[C@@]4(NCC8)C9=C8C%10=CC(OC)=CC=C%10N9)([H])C5=C7OC(C)=O
Biological Activity: Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
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Lurbinectedin | 99.70% | Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively. | ||||||||||||||||||||
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Lurbinectedin-d3 | 98.71% | Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively. | ||||||||||||||||||||
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Lurbinectedin-d4 | Lurbinectedin-d4 (PM01183-d4) is the deuterated-labeled Lurbinectedin (HY-16293). Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively. | |||||||||||||||||||||
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