49863-48-1
Chemical Structure
Verdamicin
- CAS No.: 49863-48-1
- Formula:C20H39N5O7
- Molecular Weight:461.55
IUPAC Name: 2-((4,6-diamino-3-((3-amino-6-(1-aminoethyl)-3,4-dihydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol
InChIKey: XUSXOPRDIDWMFO-CTMSJIKGSA-N
SMILES: O[C@H]1[C@@H](O[C@@H]2[C@H]([C@@H]([C@H](C[C@H]2N)N)O[C@H]3OC([C@H](C)N)=CC[C@H]3N)O)OC[C@@](C)([C@@H]1NC)O
Biological Activity: Verdamicin is an aminoglycoside antibiotic isolated from Micromonospora grisea, exhibiting broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Verdamicin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Verdamicin exerts bactericidal effects against Gram-negative and Gram-positive isolates. Verdamicin can be used for research on bacterial infections[1][2][3][4].
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Verdamicin | Verdamicin is an aminoglycoside antibiotic isolated from Micromonospora grisea, exhibiting broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Verdamicin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Verdamicin exerts bactericidal effects against Gram-negative and Gram-positive isolates. Verdamicin can be used for research on bacterial infections. | |||||||||||||||||||||
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References
- [1]. Li CR, et al. In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme. Antimicrobial agents and chemotherapy. 2008 Nov;52(11):3875-82.
- [2]. Kase H, et al. Biotransformation of Sisomicin and Verdamicin by Micromonospora sagamiensis. Agricultural and Biological Chemistry. 1982;46(2):515-522.
- [3]. Weinstein MJ, et al. Verdamicin, a new broad spectrum aminoglycoside antibiotic. Antimicrobial agents and chemotherapy. 1975 Mar;7(3):246-9. [Content Brief]
- [4]. Yu PK, et al. Comparison of in vitro antibacterial activities of gentamicin and verdamicin. Antimicrobial agents and chemotherapy. 1974 Oct;6(4):526-8.
