500170-27-4
![d[Cha4]-AVP Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p1390.gif "d[Cha4]-AVP Chemical Structure")
Chemical Structure
d[Cha4]-AVP
- CAS No.: 500170-27-4
- Formula:C50H71N13O11S2
- Molecular Weight:1094.31
IUPAC Name: (S)-1-((4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-(cyclohexylmethyl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
InChIKey: ZKYCVZNKBXGNEK-ZTYVOHGWSA-N
SMILES: O=C(N1[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O)CCC1)[C@H]2NC([C@H](CC(N)=O)NC([C@H](CC3CCCCC3)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)NC(CCSSC2)=O)=O)=O)=O)=O
Biological Activity: d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].
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d[Cha4]-AVP | 98.34% | d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors. | ||||||||||||||||||||
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References
- [1]. Ling Ling Cheng, et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. [Content Brief]
- [2]. Cristiana Griffante, et al. Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist. Br J Pharmacol. 2005 Nov;146(5):744-51. [Content Brief]
