501010-06-6
501010-06-6
Chemical Structure
Camprenstat
Synonym(s): GGTI-2418
- CAS No.: 501010-06-6
- Formula:C23H31N5O4
- Molecular Weight:441.52
IUPAC Name: ((S)-2-benzyl-4-((4-methyl-1H-imidazol-5-yl)methyl)-3-oxopiperazine-1-carbonyl)-L-leucine
InChIKey: COLCNDRDBCLVOC-ICSRJNTNSA-N
SMILES: CC(C)C[C@@H](C(O)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O
Biological Activity: Camprenstat (GGTI-2418) is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. Camprenstat inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. Camprenstat also increases p27(Kip1) and induces significant regression of breast tumors[1].
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Camprenstat | 99.91% | Camprenstat (GGTI-2418) is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. Camprenstat inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. Camprenstat also increases p27(Kip1) and induces significant regression of breast tumors. | ||||||||||||||||||||
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