503443-09-2
Chemical Structure
Dendroside D
- CAS No.: 503443-09-2
- Formula:C27H44O14
- Molecular Weight:592.64
IUPAC Name: (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (1R,1aR,4S,4aS,7R,7aS,7bS)-4-hydroxy-1,7-dimethyl-4-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)decahydro-1H-cyclopropa[e]azulene-1-carboxylate
InChIKey: LRLWNFCOLQJNHA-KNCJFJOOSA-N
SMILES: C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@@]2(C)[C@@]3([C@]2(CC[C@](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)(O)[C@@]5([C@]3([C@H](C)CC5)[H])[H])[H])[H]
Biological Activity: Dendroside D is a sesquiterpenoid compound. Dendroside D binds to the RNA site of RNA-dependent RNA polymerase and the active site of SARS-CoV-2 main protease through hydrogen bonds, electrostatic interactions, and hydrophobic interactions, thereby blocking viral replication. Dendroside D stimulates the proliferation of mouse T and B lymphocytes, promotes T and B lymphocyte proliferation, and exhibits immunomodulatory activity. Dendroside D can be used for viral infection and immune-related research[1][2][3][4][5].
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Dendroside D | Dendroside D is a sesquiterpenoid compound. Dendroside D binds to the RNA site of RNA-dependent RNA polymerase and the active site of SARS-CoV-2 main protease through hydrogen bonds, electrostatic interactions, and hydrophobic interactions, thereby blocking viral replication. Dendroside D stimulates the proliferation of mouse T and B lymphocytes, promotes T and B lymphocyte proliferation, and exhibits immunomodulatory activity. Dendroside D can be used for viral infection and immune-related research. | |||||||||||||||||||||
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References
- [1]. Mohamed EM, et al. Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis. Molecules. 2020 Apr 8;25(7):1714.
- [2]. Ye Q, et al. Immunomodulatory sesquiterpene glycosides from Dendrobium nobile. Phytochemistry. 2002 Dec;61(8):885-90.
- [3]. Li J, et al. The Chemical Structure and Pharmacological Activity of Sesquiterpenoids in Dendrobium Sw. Molecules. 2024 Dec 11;29(24):5851.
- [4]. Rafli M, et al. Potential of Dendrobium spp. Secondary Metabolites as Medicinal Source for SARS‑CoV‑2. In: Proceedings of the 7th International Conference on Biological Science (ICBS 2021); 2021 Oct 14‑15; Yogyakarta, Indonesia. Advances in Biological Sciences Research. Atlantis Press; 2022.
- [5]. Kinasih A, et al In Silico Study of Secondary Metabolites in Dendrobium spp. as SARS‑CoV‑2 Antivirus on Main Protease (Mpro). Jurnal Riset Biologi dan Aplikasinya. 2022 Mar;4(1):19‑25.
