503605-66-1
503605-66-1
Chemical Structure
Adecatumumab
Synonym(s): MT 201; Anti-Human EPCAM Recombinant Antibody
- CAS No.: 503605-66-1
- Formula:N/A
- Molecular Weight:(147.52 kDa)
IUPAC Name: 3-((2-chlorophenyl)amino)-2-cyano-3-thioxo-N-(3-(trifluoromethyl)phenyl)propanamide
SMILES: [Adecatumumab]
Biological Activity: Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status[1][2].
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Adecatumumab | 99.54% | Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status. | ||||||||||||||||||||
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References
- [1]. Kurtz JE, et al. Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opin Biol Ther. 2010 Jun;10(6):951-8. [Content Brief]
- [2]. Lutterbuese P, et al. Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model. Cancer Immunol Immunother. 2007 Apr;56(4):459-68. [Content Brief]
