503612-47-3
503612-47-3
Chemical Structure
Apixaban
Synonym(s): BMS-562247-01
- CAS No.: 503612-47-3
- Formula:C25H25N5O4
- Molecular Weight:459.50
IUPAC Name: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
InChIKey: QNZCBYKSOIHPEH-UHFFFAOYSA-N
SMILES: NC(C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C5=CC=C(C=C5)OC)=O
Biological Activity: Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[2].
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Apixaban | 99.99% | Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases. | ||||||||||||||||||||
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Apixaban (Standard) | 99.95% | Apixaban (Standard) is the analytical standard of Apixaban. This product is intended for research and analytical applications. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases. | ||||||||||||||||||||
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Apixaban-13C,d3 | 97.11% | Apixaban-13C,d3 (BMS-562247-01-13C,d3) is a deuterium and 13C labeled Apixaban (HY-50667). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. | ||||||||||||||||||||
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Apixaban-d3 | 99.9% | Apixaban-d3 (BMS-562247-01-d3) is the deuterium labeled Apixaban (HY-50667). Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Kis of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases. | ||||||||||||||||||||
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O-Desmethyl apixaban sulfate | O-Desmethyl apixaban sulfate is the major circulating metabolite of Apixaban (HY-50667) in humans. O-Desmethyl apixaban sulfate exhibits no inhibitory activity against human activated factor X (FXa), with a Ki > 20 μM. | |||||||||||||||||||||
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O-Desmethyl apixaban | 99.51% | O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. | ||||||||||||||||||||
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Apixaban impurity 41 | 99.88% | Apixaban impurity 41 is an impurity of Apixaban (HY-50667). | ||||||||||||||||||||
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Apixaban impurity 41 (Standard) | ≥98% | 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid (Standard) is the analytical standard of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Apixaban acid-13C,d3 | Apixaban acid-13C,d3 is the deuterium and 13C labeled Apixaban acid. | |||||||||||||||||||||
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Apixaban impurity 47 | 99.34% | Apixaban impurity 47 is an impurity of Apixaban. | ||||||||||||||||||||
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1-(4-Chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide | 99.56% | 1-(4-Chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Apixaban impurity 3 | Apixaban impurity 3 is an impurity of Apixaban (HY-50667). | |||||||||||||||||||||
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5''-Methyl-apixaban | 5''-Methyl-apixaban is a drug impurity. | |||||||||||||||||||||
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Apixaban impurity 23 | Apixaban impurity 23 is an impurity of Apixaban. | |||||||||||||||||||||
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Apixaban impurity 10 | Apixaban impurity 10 is an impurity of Apixaban. | |||||||||||||||||||||
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References
- [1]. Pinto DJ, et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem. 2007 Nov 1;50(22):5339-56. [Content Brief]
- [2]. Wong PC, et al. Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. J Thromb Haemost. 2008 May;6(5):820-9 [Content Brief]
