503612-76-8
503612-76-8
Chemical Structure
O-Desmethyl apixaban
- CAS No.: 503612-76-8
- Formula:C24H23N5O4
- Molecular Weight:445.47
IUPAC Name: 1-(4-hydroxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
InChIKey: HGHLWAZFIGRAOT-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C2=CC=C(O)C=C2)C3=C1CCN(C4=CC=C(N5C(CCCC5)=O)C=C4)C3=O)N
Biological Activity: O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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O-Desmethyl apixaban | 99.51% | O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. | ||||||||||||||||||||
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O-Desmethyl apixaban (Standard) | ≥98% | O-Desmethyl apixaban (Standard) is the analytical standard of O-Desmethyl apixaban. This product is intended for research and analytical applications. O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. | ||||||||||||||||||||
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References
- [1]. Pinto DJ, et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blo [Content Brief]
- [2]. Raghavan N, et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos. 2009 Jan;37(1):74-81. [Content Brief]
