50655-17-9
Chemical Structure
8-Benzylthio-cAMP
- CAS No.: 50655-17-9
- Formula:C17H17N5NaO6PS
- Molecular Weight:473.38
IUPAC Name: sodium (4aR,6R,7R,7aS)-6-(6-amino-8-(benzylthio)-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
InChIKey: RUPKCPUFUGQGAS-KHXPSBENSA-M
SMILES: NC1=C2C(N([C@H]3[C@@H]([C@@]4([H])[C@](COP(O4)(O[Na])=O)([H])O3)O)C(SCC5=CC=CC=C5)=N2)=NC=N1
Biological Activity: 8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis[1].
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8-Benzylthio-cAMP | 8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis. | |||||||||||||||||||||
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References
- [1]. KATAOKA S, et al. Studies on the Synthesis of Compounds Related to Adenosine 3', 5'-Cyclic Phosphate. V.: Synthesis and Cardiac Effect of N6-Alkyladenosine 3', 5'-Cyclic Phosphates and Their 8-Benzylthio Derivatives[J]. Chemical and pharmaceutical bulletin, 1988, 36(6): 2212-2219. [Content Brief]
