50743-17-4
50743-17-4
Chemical Structure
3-Cyanochromone
- CAS No.: 50743-17-4
- Formula:C10H5NO2
- Molecular Weight:171.16
IUPAC Name: 4-oxo-4H-chromene-3-carbonitrile
InChIKey: SFWNPLLGXKJESA-UHFFFAOYSA-N
SMILES: N#CC1=COC=2C=CC=CC2C1=O
Biological Activity: 3-Cyanochromone (Compound fragment 1) is a dual NDM-1 and VIM-2 inhibitor with KD values of 181 μM and 999 μM, respectively. 3-Cyanochromone is promising for research of antibiotics[1][2].
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3-Cyanochromone | 3-Cyanochromone (Compound fragment 1) is a dual NDM-1 and VIM-2 inhibitor with KD values of 181 μM and 999 μM, respectively. 3-Cyanochromone is promising for research of antibiotics. | |||||||||||||||||||||
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References
- [1]. Christopeit T, et al. Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2. Bioorg Med Chem Lett. 2016 Apr 15;26(8):1973-7. [Content Brief]
- [2]. Xiao Q, et al. Silver-catalyzed cascade reactions of 3-cyanochromone with 1, 1-enediamines: synthesis of highly functionalized 2-(pyridin-3-yl)-chromeno [2, 3-d] pyrimidines[J]. Organic Chemistry Frontiers, 2020, 7(15): 2035-2039.
