508-04-3
Chemical Structure
δ-Amyrin
Synonym(s): (-)-δ-Amyrin; δ-Amyrenol
- CAS No.: 508-04-3
- Formula:C30H50O
- Molecular Weight:426.72
IUPAC Name: (3S,4aR,6aR,6bS,8aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,13,14,14a,14b-icosahydropicen-3-ol
InChIKey: JOCIRBSYAYKMEF-YDPPSCFKSA-N
SMILES: CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CCC4=C5CC(C)(C)CC[C@@](C)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Biological Activity: δ-Amyrin ((-)-δ-Amyrin; δ-Amyrenol) is a pentacyclic triterpenoid that is isolated from the bark of Scaevola floribunda. δ-Amyrin is a CD81 receptor binding agent that occupies the active site of CD81 to impede HCV E2-mediated viral entry. δ-Amyrin also exhibits hepatoprotective activity. δ-Amyrin is used in research on hepatitis C virus infection and liver injury[1][2][3][4].
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δ-Amyrin | δ-Amyrin ((-)-δ-Amyrin; δ-Amyrenol) is a pentacyclic triterpenoid that is isolated from the bark of Scaevola floribunda. δ-Amyrin is a CD81 receptor binding agent that occupies the active site of CD81 to impede HCV E2-mediated viral entry. δ-Amyrin also exhibits hepatoprotective activity. δ-Amyrin is used in research on hepatitis C virus infection and liver injury. | |||||||||||||||||||||
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References
- [1]. Cambie, R. C.; et al. Chemistry of Fijian Plants. 13. Floribundal, a Nonglycosidic Bisiridoid, and Six Novel Fatty Esters of δ-Amyrin from Scaevola floribunda. J. Nat. Prod. 1997, 60 (12), 1303–1306.
- [2]. Jabin A, et al. Target-specificity of different amyrin subunits in impeding HCV influx mechanism inside the human cells considering the quantum tunnel profiles and molecular strings of the CD81 receptor: a combined in silico and in vivo study. In silico pharmacology. 2023;11(1):8. [Content Brief]
- [3]. He, A.; et al. Hepatoprotective triterpenes from Sedum sarmentosum. Phytochemistry 1998, 49, 2607–2610.
- [4]. Wu S, et al. An Unexpected Oxidosqualene Cyclase Active Site Architecture in the Iris tectorum Multifunctional α-Amyrin Synthase. ACS Catal. 2020 Aug 21;10(16):9515-9520. [Content Brief]
