51022-77-6
51022-77-6
Chemical Structure
Etazolate
Synonym(s): SQ 64442
- CAS No.: 51022-77-6
- Formula:C14H19N5O2
- Molecular Weight:289.33
IUPAC Name: ethyl 1-ethyl-4-(2-(propan-2-ylidene)hydrazinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
InChIKey: OPQRBXUBWHDHPQ-UHFFFAOYSA-N
SMILES: C/C(C)=N\NC1=C2C(N(CC)N=C2)=NC=C1C(OCC)=O
Biological Activity: Etazolate (SQ 64442) is a α-secretase activator, selective PDE4 inhibitor, selective GABAA receptor modulator. Etazolate reduces IL-1β levels Etazolate exerts a dose-dependent anti-inflammatory and anti-œdematous effect accompanied by lasting memory improvement. Etazolate produces an antidepressant-like effect[1][2][3].
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Etazolate | Etazolate (SQ 64442) is a α-secretase activator, selective PDE4 inhibitor, selective GABAA receptor modulator. Etazolate reduces IL-1β levels Etazolate exerts a dose-dependent anti-inflammatory and anti-œdematous effect accompanied by lasting memory improvement. Etazolate produces an antidepressant-like effect. | |||||||||||||||||||||
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References
- [1]. Siopi E, et al. Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice. Neuropharmacology. 2013 Apr;67:183-92. [Content Brief]
- [2]. Jindal A, et al. Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy. Psychopharmacology (Berl). 2015 Feb;232(3):623-37. [Content Brief]
- [3]. Marcade M, et al. Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008 Jul;106(1):392-404. [Content Brief]
