51050-59-0
Chemical Structure
3,4-Dichloroisocoumarin
- CAS No.: 51050-59-0
- Formula:C9H4Cl2O2
- Molecular Weight:215.03
IUPAC Name: 3,4-dichloro-1H-isochromen-1-one
InChIKey: SUGXUUGGLDCZKB-UHFFFAOYSA-N
SMILES: ClC1=C(OC(C2=C1C=CC=C2)=O)Cl
Biological Activity: 3,4-Dichloroisocoumarin is a potent serine-protease and SrLip inhibitor (Ki for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms[1][2][3][4][5].
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3,4-Dichloroisocoumarin | 99.68% | 3,4-Dichloroisocoumarin is a potent serine-protease and SrLip inhibitor (Ki for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms. | ||||||||||||||||||||
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References
- [1]. Hameed A, et al. 3,4-Dichloroisocoumarin serine protease inhibitor induces DNA fragmentation and apoptosis in susceptible target cells. Proc Soc Exp Biol Med. 1998 Nov;219(2):132-7. [Content Brief]
- [2]. Anees M, et al. Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives. J Enzyme Inhib. 1994;8(3):213-21. [Content Brief]
- [3]. Pereira ME, et al. 3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex. J Biol Chem. 1992 Apr 15;267(11):7949-55. [Content Brief]
- [4]. Ašler IL, et al. Inhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin. J Enzyme Inhib Med Chem. 2013 Oct;28(5):1094-104. [Content Brief]
- [5]. Minatoguchi S, et al. Caspase-dependent and serine protease-dependent DNA fragmentation of myocytes in the ischemia-reperfused rabbit heart: these inhibitors do not reduce infarct size. Jpn Circ J. 2001 Oct;65(10):907-11. [Content Brief]
