5118-29-6
5118-29-6
Chemical Structure
Melitracen
Synonym(s): Melitracene; N 7001; Trausabun
- CAS No.: 5118-29-6
- Formula:C21H25N
- Molecular Weight:291.43
IUPAC Name: 3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine
InChIKey: GWWLWDURRGNSRS-UHFFFAOYSA-N
SMILES: CN(CC/C=C1C2=C(C(C)(C3=CC=CC=C\13)C)C=CC=C2)C
Biological Activity: Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety[1][2].
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Melitracen | Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety. | |||||||||||||||||||||
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References
- [1]. Shimamoto K, et al. Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat. Acta Sch Med Univ Kioto. 1967 Jul;40(1):25-37. [Content Brief]
- [2]. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology (Berl). 1978 Dec 15;60(1):13-8. doi: 10.1007/BF00429172. PMID: 104340. [Content Brief]
