51415-08-8
Chemical Structure
Momilactone B
- CAS No.: 51415-08-8
- Formula:C20H26O4
- Molecular Weight:330.42
IUPAC Name: 3-hydroxy-3a,8-dimethyl-8-vinyl-2,3,3a,3a1,5a,7,8,9,10,10a-decahydro-1H,4H-3,10b-(epoxymethano)phenanthro[10,1-bc]furan-4-one
InChIKey: SONPFFIKLYCKOY-YCLZOZFNSA-N
SMILES: O=C1O[C@]2([H])C=C3[C@](CC[C@@](C)(C=C)C3)([H])[C@@]4(CC5)[C@]2([H])[C@]1(C)[C@@]5(O)OC4
Biological Activity: Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase. Momilactone B upregulates the expression of p21Waf1/Cip1, reduces the kinase activity of Cdk4 and Cdk6, induces cell cycle arrest and apoptosis in cancer cells, and triggers irreversible cell death via cell membrane damage. Momilactone B inhibits the growth of neighboring plant species and serves as a major contributing factor to the allelopathy of rice. Momilactone B can be used in studies related to rice allelopathy, type 2 diabetes, colon cancer and leukemia[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Momilactone B | 99.47% | Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase. Momilactone B upregulates the expression of p21Waf1/Cip1, reduces the kinase activity of Cdk4 and Cdk6, induces cell cycle arrest and apoptosis in cancer cells, and triggers irreversible cell death via cell membrane damage. Momilactone B inhibits the growth of neighboring plant species and serves as a major contributing factor to the allelopathy of rice. Momilactone B can be used in studies related to rice allelopathy, type 2 diabetes, colon cancer and leukemia. | ||||||||||||||||||||
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References
- [1]. Quan NV, et al. Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors. Molecules (Basel, Switzerland). 2019 Jan 29;24(3):482. [Content Brief]
- [2]. Kim SJ, et al. Cytotoxic and antitumor activity of momilactone B from rice hulls. Journal of agricultural and food chemistry. 2007 Mar 07;55(5):1702-6. [Content Brief]
- [3]. Kato-Noguchi H. The Role of Momilactones in Rice Allelopathy. Journal of Chemical Ecology, 2013, 39: 175-185.
- [4]. Park C, et al. Momilactone B induces apoptosis and G1 arrest of the cell cycle in human monocytic leukemia U937 cells through downregulation of pRB phosphorylation and induction of the cyclin-dependent kinase inhibitor p21Waf1/Cip1. Oncology reports. 2014 Apr;31(4):1653-60. [Content Brief]
