51529-01-2
51529-01-2
Chemical Structure
cis-(Z)-Flupentixol dihydrochloride
Synonym(s): cis-(Z)-Flupenthixol dihydrochloride
- CAS No.: 51529-01-2
- Formula:C23H27Cl2F3N2OS
- Molecular Weight:507.44
IUPAC Name: (Z)-2-(4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethan-1-ol dihydrochloride
InChIKey: IOVDQEIIMOZNNA-MHKBYHAFSA-N
SMILES: OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
Biological Activity: cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2].
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cis-(Z)-Flupentixol dihydrochloride | cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively. | |||||||||||||||||||||
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References
- [1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6. [Content Brief]
- [2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. [Content Brief]
