518063-75-7
518063-75-7
Chemical Structure
Antifolate agent 1
- CAS No.: 518063-75-7
- Formula:C19H19N5O6
- Molecular Weight:413.38
IUPAC Name: (4-((2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)methyl)benzoyl)-L-glutamic acid
InChIKey: LHMUZCZEUVKRGD-ZDUSSCGKSA-N
SMILES: O=C1C2=C(NC(N)=N1)NC(CC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=C2
Biological Activity: Antifolate agent 1 is a 6-substituted pyrrolopyrimidine antifolate with a 1-carbon bridge. Antifolate agent 1 shows no activity against cells expressing FRα and FRβ, and has no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control in the development of folate receptor-targeted antifolates[1].
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Antifolate agent 1 | Antifolate agent 1 is a 6-substituted pyrrolopyrimidine antifolate with a 1-carbon bridge. Antifolate agent 1 shows no activity against cells expressing FRα and FRβ, and has no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control in the development of folate receptor-targeted antifolates. | |||||||||||||||||||||
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