51887-62-8
51887-62-8
Chemical Structure
(Sar1,Gly8)-Angiotensin II
- CAS No.: 51887-62-8
- Formula:C42H65N13O10
- Molecular Weight:912.05
InChIKey: NRJXBSMDHPMIPQ-SRRHRALWSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(NCC(O)=O)=O)=O)=O)=O
Biological Activity: (Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (Ki: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II[1].
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(Sar1,Gly8)-Angiotensin II | (Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (Ki: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II. | |||||||||||||||||||||
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