521298-46-4
521298-46-4
Chemical Structure
SAL-0010042
- CAS No.: 521298-46-4
- Formula:C15H15FN4O
- Molecular Weight:286.30
InChIKey: QWTNEJGXUCJWPY-UHFFFAOYSA-N
SMILES: O=C1N=C(CC2=C(F)C=CC=C2)NC3=C1NN=C3C(C)C
Biological Activity: SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM). SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM[1].
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SAL-0010042 | SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM). SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM. | |||||||||||||||||||||
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