52328-96-8
Chemical Structure
Bisdemethoxycurcumin
- CAS No.: 52328-96-8
- Formula:C19H16O4
- Molecular Weight:308.33
IUPAC Name: (1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-one
InChIKey: YXAKCQIIROBKOP-HSSGTREWSA-N
SMILES: O=C(/C=C(O)/C=C/C1=CC=C(O)C=C1)/C=C/C2=CC=C(O)C=C2
Biological Activity: Bisdemethoxycurcumin is an orally effective curcuminoid. Bisdemethoxycurcumin downregulates pro-inflammatory cytokines in macrophages by inhibiting the phosphorylation of PI3K/Akt and p38 MAPK. Bisdemethoxycurcumin relieves autophagy inhibition and promotes lipophagy to clear vascular smooth muscle foam cells by inhibiting the PDK1/Akt/mTOR pathway. Bisdemethoxycurcumin activates the cAMP/Epac/AMPKα axis and the NRF2/HO-1 antioxidant axis, thereby indirectly inhibiting the phosphorylation of NF-κB p65 and pro-inflammatory outputs such as IL-1β/IL-6/TNF-α, so as to alleviate pulmonary oxidative stress, inflammatory infiltration and pulmonary edema. Bisdemethoxycurcumin blocks NLRP3-mediated pyroptosis and protects cartilage extracellular matrix degradation by activating NRF2/HO-1. Bisdemethoxycurcumin also exerts a synergistic effect with potassium iodide against Candida[1][2][3][4][6].
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Bisdemethoxycurcumin | Bisdemethoxycurcumin is an orally effective curcuminoid. Bisdemethoxycurcumin downregulates pro-inflammatory cytokines in macrophages by inhibiting the phosphorylation of PI3K/Akt and p38 MAPK. Bisdemethoxycurcumin relieves autophagy inhibition and promotes lipophagy to clear vascular smooth muscle foam cells by inhibiting the PDK1/Akt/mTOR pathway. Bisdemethoxycurcumin activates the cAMP/Epac/AMPKα axis and the NRF2/HO-1 antioxidant axis, thereby indirectly inhibiting the phosphorylation of NF-κB p65 and pro-inflammatory outputs such as IL-1β/IL-6/TNF-α, so as to alleviate pulmonary oxidative stress, inflammatory infiltration and pulmonary edema. Bisdemethoxycurcumin blocks NLRP3-mediated pyroptosis and protects cartilage extracellular matrix degradation by activating NRF2/HO-1. Bisdemethoxycurcumin also exerts a synergistic effect with potassium iodide against Candida. | |||||||||||||||||||||
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References
- [1]. Wu H, et al. Investigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification. Molecules (Basel, Switzerland). 2022 Dec 21;28(1):68.
- [2]. Jin G, et al. Bisdemethoxycurcumin, a curcumin, protects chondrocytes, and reduces cartilage inflammation via the NRF2/HO-1/NLRP3 pathway. Immunity, inflammation and disease. 2024 Feb;12(2):e1195.
- [3]. Zuo J, et al. Bisdemethoxycurcumin suppresses the progression of atherosclerosis and VSMC-derived foam cell formation by promoting lipophagy. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Dec;396(12):3659-3670. [Content Brief]
- [4]. Li H, et al. Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPKα pathway. BMC pharmacology & toxicology. 2023 Nov 20;24(1):63. [Content Brief]
- [6]. Damrongrungruang T, et al. Combined bisdemethoxycurcumin and potassium iodide-mediated antimicrobial photodynamic therapy. Heliyon. 2023 Jul;9(7):e17490. [Content Brief]
