52386-42-2
Chemical Structure
Ketotrexate sodium
Synonym(s): Emofolin sodium; 5-methyltetrahydrohomofolate sodium; NSC 139490 sodium
- CAS No.: 52386-42-2
- Formula:C21H25N7Na2O6
- Molecular Weight:517.45
IUPAC Name: sodium (4-((2-(2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)ethyl)amino)benzoyl)-L-glutamate
InChIKey: PASPSZYIMAFFFK-HNYZGNTBSA-L
SMILES: O=C(CC[C@H](NC(C1=CC=C(C=C1)NCCC2N(C3=C(NC2)NC(N)=NC3=O)C)=O)C(O[Na])=O)O[Na]
Biological Activity: Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA). Ketotrexate sodium is used in research into cancer and autoimmune diseases[1][2].
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Ketotrexate sodium | Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA). Ketotrexate sodium is used in research into cancer and autoimmune diseases. | |||||||||||||||||||||
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References
- [1]. Puig L. Methotrexate: new therapeutic approaches. Actas Dermosifiliogr. 2014 Jul-Aug;105(6):583-9. [Content Brief]
- [2]. Torres RP, et al. Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis. ARP Rheumatol. 2022 Oct 1;1(3):225-229. [Content Brief]
