52423-57-1
Chemical Structure
Declopramide hydrochloride
Synonym(s): 3-Chloroprocainamide hydrochloride
- CAS No.: 52423-57-1
- Formula:C13H21Cl2N3O
- Molecular Weight:306.23
InChIKey: DMJHWHGTAHHHMU-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(Cl)=C1)N)NCCN(CC)CC.Cl
Biological Activity: Declopramide (3-Chloroprocainamide) hydrochloride is an orally active, blood-brain barrier-permeable IκBβ/NF-κB inhibitor and chemosensitizer. Declopramide exhibits affinity for rabbit 5-HT3 receptors (5-HT3R) with a Ki value of 3.2 μM. Declopramide inhibits IκBβ degradation, blocks NFκB activation, and induces rapid apoptosis and DNA strand breaks in cancer cells. Declopramide enhances the cytotoxicity induced by Cisplatin (HY-17394) and is also metabolically converted to N-acetyl declopramide. Declopramide can be used in the research of tumors such as brain astrocytoma[1][2][3].
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Declopramide hydrochloride | Declopramide (3-Chloroprocainamide) hydrochloride is an orally active, blood-brain barrier-permeable IκBβ/NF-κB inhibitor and chemosensitizer. Declopramide exhibits affinity for rabbit 5-HT3 receptors (5-HT3R) with a Ki value of 3.2 μM. Declopramide inhibits IκBβ degradation, blocks NFκB activation, and induces rapid apoptosis and DNA strand breaks in cancer cells. Declopramide enhances the cytotoxicity induced by Cisplatin (HY-17394) and is also metabolically converted to N-acetyl declopramide. Declopramide can be used in the research of tumors such as brain astrocytoma. | |||||||||||||||||||||
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