52434-75-0
52434-75-0
Chemical Structure
LHRH (1-5) free acid
- CAS No.: 52434-75-0
- Formula:C34H38N8O9
- Molecular Weight:702.71
InChIKey: VVBDLEHCIKUJSA-XLIKFSOKSA-N
SMILES: O=C([C@H]1NC(CC1)=O)N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(O)=O)CC3=CC=C(C=C3)O)=O)=O)CC4=CNC5=CC=CC=C45)=O
Biological Activity: LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983)[1][2].
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LHRH (1-5) free acid | LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983). | |||||||||||||||||||||
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References
- [1]. McDermott JR, et al. Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases. Peptides. 1983 Jan-Feb;4(1):25-30. [Content Brief]
- [2]. Yokosawa H, et al. Degradation of luteinizing hormone-releasing hormone by neuroblastoma cells and their membrane: evidence for the involvement of a thiol protease and angiotensin-converting enzyme. J Neurochem. 1987 Jan;48(1):293-8. [Content Brief]
