52438-21-8
52438-21-8
Chemical Structure
1-Cinnamoylpyrrolidine
- CAS No.: 52438-21-8
- Formula:C13H15NO
- Molecular Weight:201.26
IUPAC Name: (E)-3-phenyl-1-(pyrrolidin-1-yl)prop-2-en-1-one
InChIKey: JSIGICUAXLIURX-CMDGGOBGSA-N
SMILES: O=C(N1CCCC1)/C=C/C2=CC=CC=C2
Biological Activity: 1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA[1]. 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM[2].
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1-Cinnamoylpyrrolidine | 1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA. 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM. | |||||||||||||||||||||
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References
- [1]. Send toBioorg Med Chem.Ma J, et al. Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum. Bioorg Med Chem. 2004 Jul 15;12(14):3885-9. [Content Brief]
- [2]. Chen IS, et al. Amides with anti-platelet aggregation activity from Piper taiwanense. Fitoterapia. 2007 Sep;78(6):414-9. Epub 2007 May 24. [Content Brief]
