530-43-8
Chemical Structure
Chloramphenicol palmitate
- CAS No.: 530-43-8
- Formula:C27H42Cl2N2O6
- Molecular Weight:561.54
IUPAC Name: (2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propyl palmitate
InChIKey: PXKHGMGELZGJQE-ILBGXUMGSA-N
SMILES: CCCCCCCCCCCCCCCC(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)=O
Biological Activity: Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830). Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic[1][2][3][4][5].
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Chloramphenicol palmitate | 98.25% | Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830). Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic. | ||||||||||||||||||||
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Chloramphenicol palmitate (Standard) | ≥98% | Chloramphenicol palmitate (Standard) is the analytical standard of Chloramphenicol palmitate (HY-B1599). This product is intended for research and analytical applications. Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830). Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic. | ||||||||||||||||||||
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References
- [1]. Siti Nani Nurbaeti, et al. Sustained-release Microparticle Dry Powders of Chloramphenicol Palmitate or Thiamphenicol Palmitate Prodrugs for Lung Delivery as Aerosols.Eur J Pharm Sci. 2019 Oct 1;138:105028. [Content Brief]
- [2]. Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9(3):222-38. [Content Brief]
- [3]. Gassner B, et al. Pharmacokinetic and toxicological aspects of the medication of beef-type calves with an oral formulation of chloramphenicol palmitate. J Vet Pharmacol Ther. 1994 Aug;17(4):279-83. [Content Brief]
- [4]. Dhingra A K, et al. Promoiety: A versatile tool for improving drug acceptability. Innovations in Pharmaceuticals and Pharmacotherapy, 2019, 7: 1-6.
- [5]. Wang R, et al. Substrate imprinted lipase nanogel for one-step synthesis of chloramphenicol palmitate. Green Chemistry, 2013, 15(5): 1155-1158.
