53126-63-9
53126-63-9
Chemical Structure
Satratoxin G
- CAS No.: 53126-63-9
- Formula:C29H36O10
- Molecular Weight:544.59
InChIKey: GTONGKBINDTWOM-DUKGXRRLSA-N
SMILES: CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@](C[C@H]3OC(/C=C\C=C\[C@@]5(C(O)C)[C@H](O)[C@@]6(C7O6)CCO5)=O)([H])O2)(COC7=O)CC1
Biological Activity: Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Satratoxin G | 99.5% | Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase . | ||||||||||||||||||||
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Verrucarin A | 99.90% | Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53. | ||||||||||||||||||||
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Satratoxin H | 99.7% | Satratoxin H is a toxic metabolite of Stachybotrys atra. Satratoxin H induces caspase-3 and PARP cleavage via p38 MAPK and JNK pathways, stimulates JNK, ERK, and p38 MAPK phosphorylation, and activates JNK and p38 MAPK in a glutathione-sensitive manner. Satratoxin H induces DNA double-stranded breaks, apoptotic body formation, intracellular reactive oxygen species generation, and endoplasmic reticulum stress via ATF6, PERK, and IRE1 pathways. Satratoxin H can be used for the research of central nervous system disorders and melanoma. | ||||||||||||||||||||
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Roridin E | 99.89% | Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies. | ||||||||||||||||||||
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Mytoxin B | Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway. | |||||||||||||||||||||
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Verrucarin J | 99.90% | Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL. | ||||||||||||||||||||
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Roridin H | Roridin H (Verrucarin H) is a cytostatic antibiotic present in the Myrothecium verrucaria strain and the marine-derived Myrothecium sp. TUF 02F6. The IC50 of Roridin H against mouse leukemia cells is 0.12 mM. Roridin H can be used in leukemia-related research. | |||||||||||||||||||||
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8-Acetylverrucarin L | 8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum. | |||||||||||||||||||||
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Roridin J | Roridin J is a macrocyclic trichothecene and has anti-leukemia effect in mice. | |||||||||||||||||||||
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Roridin D | Roridin D is a natural compound foun in Myrothecium roridum S-1135 (NRRL 3005). | |||||||||||||||||||||
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Roridin A | 99.49% | Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita). | ||||||||||||||||||||
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References
- [1]. Nagase M, et al. Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol Lett. 2002 Oct 21;84(1):23-7. [Content Brief]
- [2]. Islam Z, et al. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ Health Perspect. 2006 Jul;114(7):1099-107. [Content Brief]
