531553-69-2
531553-69-2
Chemical Structure
Im-m7GDP
- CAS No.: 531553-69-2
- Formula:C14H19N7O10P2
- Molecular Weight:507.29
InChIKey: FSLUCUBHOZVVQK-QYVSTXNMSA-N
SMILES: O=C1C([N+](C)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(O)(N4C=CN=C4)=O)=O)O3)=C2NC(N)=N1
Biological Activity: Im-m7GDP is a capping reagent and also the P-imidazolide of N7-methylguanosine 5'-diphosphate. Im-m7GDP introduces an m7G cap structure to the monophosphate group of branched oligoribonucleotides, and is used in nucleic acid synthesis-related research[1][2][3].
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Im-m7GDP | Im-m7GDP is a capping reagent and also the P-imidazolide of N7-methylguanosine 5'-diphosphate. Im-m7GDP introduces an m7G cap structure to the monophosphate group of branched oligoribonucleotides, and is used in nucleic acid synthesis-related research. | |||||||||||||||||||||
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References
- [1]. Geng J, et al. Cap-related modifications of RNA regulate binding to IFIT proteins. RNA (New York, N.Y.). 2024 Sep 16;30(10):1292-1305. [Content Brief]
- [2]. Fukuchi K, et al. Internal cap-initiated translation for efficient protein production from circular mRNA. Nature biotechnology. 2026 Jan;44(1):120-132. [Content Brief]
- [3]. Ohashi S, et al. Selection of Short 5'-UTR of Chemically Synthesized mRNA to Improve Translation Efficiency. Chemical & pharmaceutical bulletin. 2025;73(5):449-456. [Content Brief]
